Advances in Radiation Oncology in Lung Cancer by Dusan Milanovic (auth.), Branislav Jeremic (eds.) PDF

By Dusan Milanovic (auth.), Branislav Jeremic (eds.)

ISBN-10: 3642199240

ISBN-13: 9783642199240

Although a long time of laboratory and medical study have resulted in incremental development in remedy end result, lung melanoma continues to be essentially the most lethal ailments. within the moment, thoroughly up to date variation of this accomplished booklet, a few of the world’s prime lung melanoma experts talk about the new advances within the radiation oncology of lung melanoma and give some thought to the newest examine findings. the 1st 3 sections hide the elemental technological know-how of lung melanoma, medical investigations, together with histology and staging, and a variety of basic therapy issues. present therapy ideas for nonsmall mobilephone and small mobile lung melanoma are then defined and evaluated intimately, with due awareness to novel ways that promise additional advancements in end result. many of the sorts of treatment-related toxicity are mentioned, and caliber of existence experiences and prognostic elements also are thought of. After comparing the newest technological and organic advances, together with IMRT, IMAT, cyber knife remedy, and tomotherapy, the ebook concludes via thorough attention of particular elements of medical study in lung melanoma.

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There are a number of potential reasons for this. Firstly, determination of treatment effect, rather than prediction of prognosis, requires serial measurement. Generally, only small samples of tumor can be obtained in a serial manner. Since MVD by definition measures the peak vessel density, use of small samples may affect accuracy and it is technically difficult to sample similar areas of 21 tumor repeatedly. Secondly, while MVD reflects some aspects of the angiogenic process, it may not be a measure of the relative dependence of a particular tumor on angiogenesis, and changes in MVD do not necessarily correlate with changes in tumor growth rate.

N Engl J Med 363:1693–1703 Kwei KA, Kim YH, Girard L et al (2008) Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer. Oncogene 27:3635–3640 Linardou H, Dahabreh IJ, Kanaloupiti D et al (2008) Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer. Lancet Oncol 9: 962–972 Liu B, Neufeld AH (2007) Activation of epidermal growth factor receptors in astrocytes: from development to neural injury.

Polymorphisms of components of the VEGF pathway also have been proposed to predict benefit from bevacizumab treatment (Schneider et al. 2008b; Schultheis et al. 2008). However, these findings have not been validated and 26 the prognostic importance of these polymorphisms in patients treated undergoing bevacizumab therapy has not been established. Bevacizumab has also been evaluated in the management of SCLC. For example, one ECOG study added bevacizumab to cisplatin and etoposide for up to four cycles and continued bevacizumab as maintenance for up to 1 year in patients with extensivestage SCLC (Horn et al.

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Advances in Radiation Oncology in Lung Cancer by Dusan Milanovic (auth.), Branislav Jeremic (eds.)


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