Read e-book online Animal Models in Eye Research PDF

By Panagiotis Antonios Tsonis

ISBN-10: 0123741696

ISBN-13: 9780123741691

The attention is a fancy sensory organ, which allows visible notion of the realm. therefore the attention has numerous tissues that do assorted initiatives. some of the most simple features of eye functionality is the sensitivity of cells to mild and its transduction although the optic nerve to the mind. diverse organisms use other ways to accomplish those projects. during this experience, eye functionality turns into an important evolutionary point besides. This e-book provides the several animal types which are regular for eye study and their specialty in comparing varied facets of eye improvement, evolution, body structure and disorder. * offers info at the significant animal types utilized in eye study together with invertebrates and vertebrates* offers researchers with details had to make a choice from version organisms* contains an introductory bankruptcy at the varieties of eyes, stressing attainable universal molecular equipment

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1A). indd 27 40 40 41 41 42 42 42 Development and Specification of the Larval Eye 43 Acknowledgments 44 References 44 the discovery of the double helix DNA structure or the genetic code. In 1910, Thomas Hunt Morgan discovered a fly in which the typical red pigmentation of the eye was missing (Fig. 1B,C). H. Morgan was awarded the Nobel Prize in Physiology and Medicine in 1933. Over the last 100 years, Drosophila has emerged as a precious model system to study various fields Drosophila as A Model System Animal Models in Eye Research 38 39 27 © 2008, Elsevier Ltd.

2007). dac encodes a novel DNA binding protein with two conserved domains, the DachBox-N and the DachBox-C. , 1997). Dac is acting downstream of ey, since dac is not required for ey expression (Fig. 3E). Furthermore, ectopic ey induces dac expression and dac function is required for ectopic eye formation by ey. The Eya family members are characterized by the presence of a conserved C-terminal EYA domain and an N-terminal EYA domain 2. , 1997), whereas the N-terminal regions are important for its co-activator function.

2A). After invagination of the optic lobe epithelium, the eye-precursors remain anterior to the optic lobe as a part of the dorsal pouch (Jurgens and Hartenstein, 1993). During head involution, cells of the eye disc form an epithelial sack of about 70 cells whose lumen remains open to the pharynx (Wolff and Ready, 1993). Early Development of the Eye-antennal Disc: Specification of Eye Versus Antenna Even though most processes in eye formation occur during late larval and pupa stages, initial steps of eye disc patterning take place already during early larval life.

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Animal Models in Eye Research by Panagiotis Antonios Tsonis


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