By Chi-Chao Chan
This publication describes experimental animal versions that mimic universal human ocular illnesses: herpetic keratitis, cataract, glaucoma, age-related macular degeneration, diabetic retinopathy, uveitis, retinitis pigmentosa, Graves’ disorder, and intraocular tumors. In conjunction, those versions replicate the variety and application of instruments used to check human illness. global specialist clinicians speak about each one version in keeping with their scientific event and the textual content is supported via various photographs and diagrams. In describing the main pertinent animal types of ophthalmic ailments, this booklet can be of curiosity to ophthalmologists, imaginative and prescient researchers, fellows, citizens and clinical students.
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Additional resources for Animal Models of Ophthalmic Diseases
1074/jbc. M105285200 Hegde KR, Henein MG, Varma SD (2003) Establishment of mouse as an animal model for study of diabetic cataracts: biochemical studies. Diabetes Obes Metab 5(2):113–119 Hejtmancik JF (2008) Congenital cataracts and their molecular genetics. Seminars Cell Dev Biol 19(2):134–149. 003 Horwitz J (2003) Alpha-crystallin. , Kinoshita JH (1980) Philly mouse: a new model of hereditary cataract. Exp Eye Res 30(1):59–68 Kador PF, Sun G, Rait VK, Rodriguez L, Ma Y, Sugiyama K (2001) Intrinsic inhibition of aldose reductase.
2003). 1 Diabetic Cataract Diabetes mellitus affects approximately 285 million people worldwide and the International Diabetes Federation reports that this is likely to increase to 439 million by 2030 (Pollreisz and Schmidt-Erfurth 2010). Premature cataract formation is one of the earliest secondary complications of diabetes and is considered a major cause of visual impairment in diabetic patients. While these cataracts can be successfully treated with surgery, diabetic patients are more susceptible to complications (Stanga et al.
Role of the lens in eye growth. J Exp Zoology 156:39–47 Davidson MG, Wormstone M, Morgan D, Malakof R, Allen J, McGahan MC (2000) Ex vivo canine lens capsular sac explants. Graefes Arch Clin Exp Ophthalmol 238(8):708–714 23 de Bustros S, Thompson JT, Michels RG, Enger C, Rice TA, Glaser BM (1988) Nuclear sclerosis after vitrectomy for idiopathic epiretinal membranes. Am J Ophthalmol 105(2):160–164 Delcourt C, Cristol JP, Tessier F, Leger CL, Michel F, Papoz L (2000) Risk factors for cortical, nuclear, and posterior subcapsular cataracts: the POLA study.
Animal Models of Ophthalmic Diseases by Chi-Chao Chan