By Stanley T. Crooke and Archie W. Prestayko (Eds.)
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Additional info for Antineoplastic Agents
Other effects such as inhibition of RNA synthesis have been shown to require much higher concentrations of mitomycin C. , 1970).
1975). The Brain Tumor Study Group has carried out an important controlled randomized trial of nitrosourea chemotherapy for patients with glioblastoma who had under gone a "definitive" surgical resection (Walker and Gehan, 1976). Patients were randomized to receive one of four postoperative treatment options: (1) BCNU, 80 mg/m2 per day on three successive days every 6-8 weeks; (2) radiation therapy (5000-6000 rads over 6-8 weeks); (3) a combination of BCNU plus radiation therapy; (4) best conventional care.
95, 985-986. 3 NITROSOUREAS Philip S. Schein I. II. III. IV. V. VI. Introduction Decomposition and Metabolism Mechanism of Action A. Alkylation B. Carbamolylation Clinical Use Clinical Toxicities Discussion References 37 38 39 39 40 41 44 46 47 I. INTRODUCTION In 1959, 1-methyl-l-nitro-3-nitrosoguanidine (MNNG) was reported to have limited but reproducible antitumor activity aginst the murine LI210 leukemia. Although it was recognized that the therapeutic potential of this compound was insufficient to warrant extensive clinical trial, the observation formed the basis of the intensive evaluation of the N-nitroso containing compounds as antitumor agents that has since occurred.
Antineoplastic Agents by Stanley T. Crooke and Archie W. Prestayko (Eds.)