Supratim Choudhuri's Bioinformatics for Beginners: Genes, Genomes, Molecular PDF

By Supratim Choudhuri

ISBN-10: 0124104711

ISBN-13: 9780124104716

Bioinformatics for newcomers: Genes, Genomes, Molecular Evolution, Databases and Analytical Tools presents a coherent and pleasant therapy of bioinformatics for any scholar or scientist inside biology who has now not commonly played bioinformatic analysis.

The e-book discusses the appropriate rules had to comprehend the theoretical underpinnings of bioinformatic research and demonstrates, with examples, unique research utilizing freely on hand web-based software program and publicly on hand databases. Eschewing non-essential details, the paintings specializes in rules and hands-on research, additionally pointing to additional learn options.

  • Avoids non-essential assurance, but absolutely describes the sphere for beginners
  • Explains the molecular foundation of evolution to put bioinformatic research in organic context
  • Provides precious hyperlinks to the titanic source of publicly on hand bioinformatic databases and research tools
  • Contains over a hundred figures that reduction in proposal discovery and representation

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Read e-book online Bioinformatics for Beginners: Genes, Genomes, Molecular PDF

Bioinformatics for newcomers: Genes, Genomes, Molecular Evolution, Databases and Analytical instruments offers a coherent and pleasant therapy of bioinformatics for any scholar or scientist inside biology who has no longer usually played bioinformatic research. The publication discusses the correct rules had to comprehend the theoretical underpinnings of bioinformatic research and demonstrates, with examples, exact research utilizing freely to be had web-based software program and publicly on hand databases.

Additional resources for Bioinformatics for Beginners: Genes, Genomes, Molecular Evolution, Databases and Analytical Tools

Example text

Genetic variations are random and spontaneous; hence they arise in the population independent of need. The advantages or disadvantages of such variations become apparent only when selection pressure arises. Thus, the natural evolutionary process works as a blind watchmaker, as Richard Dawkins calls it to underscore the lack of purpose and direction in the process. However, in recent years, the concept of directed (adaptive) mutation and directed evolution in bacteria, originally proposed in 1988 by John Cairns and coworkers,6 has garnered some support.

Yip KY, et al. Genome Biol 2012;13:R48. 3 Phylogenetic Tree 49 References 52 50 50 50 50 52 52 formation of new species (speciation), but evolution can generate diversity at all possible levels of biological organization including at the level of macromolecules, such as DNA and proteins. Molecular evolution is a relatively recent discipline that has developed since DNA and protein sequence information became available. Simply stated, molecular Probably, the shortest classical definition of evolution is descent with modification from the ancestor.

Genome sequencing shows that gene duplication is prevalent in all three domains of life (Bacteria, Archaea, Eukarya). In multicellular eukaryotes, including humans, B40À60% genes have been produced through duplication, depending on the species. Several publications have reported on the rate of gene duplication in various eukaryotic species, but the results vary significantly. e. 19 Many duplicated genes are inactivated g Orthologous genes or orthologs are homologs in different species—that is, they evolved from a common ancestral gene through speciation.

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Bioinformatics for Beginners: Genes, Genomes, Molecular Evolution, Databases and Analytical Tools by Supratim Choudhuri


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