Cicatrising Conjunctivitis (Developments in Ophthalmology) - download pdf or read online

By M.J. Elder, W. Bernauer, J.K.G. Dart, F. Bandello

ISBN-10: 3805564430

ISBN-13: 9783805564434

Cicatrizing conjunctivitis is among the such a lot difficult explanations of ocular floor ailment this present day, and with no acceptable intervention, corneal blindness or lack of sight from supervening an infection is usual. simply because lots of those illnesses are infrequent, there's frequently restricted administration event on hand and the assets for study into remedy and pathogenesis should be scarce. this article summarizes current therapy thoughts and the medical and laboratory stories validating those techniques. subject matters mentioned contain an in-depth examine non-progressive explanations together with trachoma, Stevens-Johnson syndrome and ligneous conjunctivitis. The textual content additionally examines persistent revolutionary conjunctival cicatrization, the ailments which reason it, their scientific and laboratory evaluate, immunopathogenesis, sequelae and administration. it's going to relief the making plans of intervention and remedy of a gaggle of illnesses formerly linked to negative diagnosis.

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Additional info for Cicatrising Conjunctivitis (Developments in Ophthalmology)

Sample text

Am J Ophthalmol 1984;98:429–431. Wilhelmus KR, Dunkel EC, Herson J: Topical human fibroblast interferon for acute adenoviral conjunctivitis. Graefes Arch Clin Exp Ophthalmol 1987;225:461–464. Kowalski RP, Gordon YJ: Comparison of direct rapid tests for the detection of adenovirus antigen in routine conjunctival specimens. Ophthalmology 1989;96:1106–1109. Dunkel EC, Pavan-Langston D, Fitzpatrick K, Cukor G: Rapid detection of herpes simplex virus (HSV) antigen in human ocular infections. Curr Eye Res 1988;7:661–666.

It has been accepted for some time now that there are three related conditions: erythema multiforme, sometimes called erythema multiforme minor, in which there is skin involvement but the mucous membranes are spared; erythema multiforme major, which tends to be referred to as ‘Stevens–Johnson syndrome’, in which the skin and the mucous membranes are involved, and a more severe Table 1. Drug preparations reported to have caused Stevens-Johnson syndrome Systemic medications E Sulfonamides E Phenytoin E Barbiturates E Non-steroidal anti-inflammatory agents E Penicillins E Salicylates Topical medications E Scopolamine E Sulfonamide E Tropicamide expression of the same process which has been termed ‘toxic epidermal necrolysis’ and which is sometimes referred to as ‘Lyell syndrome’ [3, 4].

Conjunctival autografts have been preferred to mucous membrane for patients who have unilateral disease. Unfortunately, the most deserving cases are usually bilateral and there is no satisfactory source of conjunctiva. For these patients, conjunctival allografts have been employed or conjunctiva has been harvested from living related donors. Some patients with Stevens–Johnson syndrome show signs of limbal stem cell deficiency. The epithelium is unstable, at worst with chronic epithelial defects and in its milder form with keratinisation and widespread staining with fluorescein or Bengal rose.

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Cicatrising Conjunctivitis (Developments in Ophthalmology) by M.J. Elder, W. Bernauer, J.K.G. Dart, F. Bandello

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