Download e-book for iPad: Combination cancer therapy : modulators and potentiators by Gary K. Schwartz

By Gary K. Schwartz

ISBN-10: 1588292002

ISBN-13: 9781588292001

ISBN-10: 1592598641

ISBN-13: 9781592598649

Professional physician-scientists and clinicians evaluate these mixtures of novel goal brokers vintage chemotherapies that carry the main promise for the way forward for clinical oncology, and aspect their optimum series, pharmacokinetic interactions, and interplay with downstream mobile indications. The combos run the gamut of certain remedies opposed to telephone floor receptors (EGF-R and HER2), the phone cycle (the CDKs), sign transduction occasions (PKC and NF-kB), apoptosis (bcl-2), in addition to concentrated cures in ovarian melanoma, hematologic ailments, and breast melanoma. The authors emphasize novel translational methods which are quickly relocating from the laboratory bench best to the patient's bedside for the longer term remedies in melanoma remedy.

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61. Naramura M, Gillies SD, Mendelsohn J, et al. Therapeutic potential of chimeric and murine anti-(epidermal growth factor receptor) antibodies in a metastasis model for human melanoma. Cancer Immunol Immunother 1993;37:343–349. 62. Clynes RA, Towers TL, Presta LG, et al. Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets. Nat Med 2000;6:443–446. 63. Bos M, Mendelsohn J, Kim YM, et al. PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner.

53. Baselga J, Mendelsohn J. The epidermal growth factor receptor as a target for therapy in breast carcinoma. Breast Cancer Res Treat 1994;29:127–138. 54. Fan Z, Masui H, Altas I, Mendelsohn J. Blockade of epidermal growth factor receptor function by bivalent and monovalent fragments of 225 anti-epidermal growth factor receptor monoclonal antibodies. Cancer Res 1993;53:4322–4328. 55. Ciardiello F, Bianco R, Damiano V, et al. Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225.

Anti-tumor activity of GW2016 in the ErbB-2 positive human breast cancer xenograft, BT-474. Proc Am Assoc Cancer Res 2001;42:A4308. 108. Rusnak DW, Lackey K, Aflleck K, et al. The effects of the novel, reversible Epidermal Growth Factor Receptor/ErbB-2 tyrosine kinase inhibitor , GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther 2001;1:85–94. 109. Fry DW, Bridges AJ, Denny WA, et al. Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor.

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Combination cancer therapy : modulators and potentiators by Gary K. Schwartz

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