Vladimir P Torchilin's Delivery of Protein and Peptide Drugs in Cancer PDF

By Vladimir P Torchilin

ISBN-10: 1860946275

ISBN-13: 9781860946271

Written through top scientists within the box of supply of protein and peptide medicines to tumors for melanoma treatment, this crucial booklet presents a extensive creation to the sector, with dialogue via key specialists at the physiological boundaries for protein and peptide medications in tumors, and the various ways to stabilization of those medicinal drugs in organic atmosphere, in addition to their more advantageous supply to tumors and inside of melanoma cells.

This ebook can be utilized as a sophisticated textbook by way of graduate scholars and younger scientists and clinicians on the early levels in their occupation. it's also compatible for non-experts from comparable components of chemistry, biochemistry, molecular biology, body structure, experimental and medical oncology and pharmaceutical sciences, who're attracted to normal difficulties of drug supply and drug focusing on in addition to in a extra really expert subject matters of utilizing protein and peptide medicines for tumor treatment.

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Additional resources for Delivery of Protein and Peptide Drugs in Cancer

Example text

89. Yuan X, et al. (2003) Lipid-mediated delivery of peptide nucleic acids to pulmonary endothelium. Biochem Biophys Res Comm 302(1):6–11. 90. Sauer I, et al. (2005) An apolipoprotein E-derived peptide mediates uptake of sterically stabilized liposomes into brain capillary endothelial cells. Biochem 44(6):2021–2029. 91. Nikol S, et al. (2002) Local perivascular application of low amounts of a plasmid encoding for vascular endothelial growth factor (VEGF165) is efficient for therapeutic angiogenesis in pigs.

Van Hinsbergh VW (2001) The endothelium: Vascular control of haemostasis. Atherosclerosis 95(2):198–201. 10. Hobbs SK, et al. (1998) Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment. Proc Natl Acad Sci USA 95:4607–4612. 11. Yuan F, et al. (1995) Vascular permeability in a human tumor xenograft: Molecular size dependence and cutoff size. Cancer Res 55:3752–3756. 12. Hudson BG, Reeders ST and Trygvason K (1993) Type IV collagen: Structure, gene organization and role in human diseases.

20. Michiels C, Arnould T and Remacle J (2000) Endothelial cell responses to hypoxia: Initiation of a cascade of cellular interactions. Biochim Biophys Acta 1497(1):1–10. 21. Charonis AS and Wissig SL (1983) Anionic sites in basement membranes. Differences in their electrostatic properties in continuous and fenestrated capillaries. Microvasc Res 25:265–285. 22. Roberts WG and Palade GE (1997) Neovasculature induced by vascular endothelial growth factor is fenestrated. Cancer Res 57(4):765–772. 23.

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Delivery of Protein and Peptide Drugs in Cancer by Vladimir P Torchilin

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