By M. Ola
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Additional resources for Diabetic Retinopathy
120] Murata T, He S, Hangai M, Ishibashi T, Xi XP, Kim S, Hsueh WA, Ryan SJ, Law RE, Hinton DR. Peroxisome proliferator-activated receptor-gamma ligands inhibit choroidal neovascularization. Invest Ophthalmol Vis Sci. 2000 Jul;41(8):2309-17.  Murugeswari P, Shukla D, Rajendran A, Kim R, Namperumalsamy P, Muthukkaruppan V. Proinflammatory cytokines and angiogenic and antiangiogenic factors in vitreous of patients with proliferative diabetic retinopathy and eales' disease. Retina. 2008 Jun;28(6):817-24.
These increased serum levels of AGE can predict changes in microvascular morphology in patients with diabetic retinopathy. , 1996). Our research team has hypothesized that increase in the titre of anti-AGE antibodies has a direct role in the pathogenesis of diabetes microvascular complications especially diabetic retinopathy. Detection and characterization of antibodies against gluco-oxidative modified proteins could help in understanding the exact aetiology of gluco-oxidation of protein and diabetic retinopathy.
Activation of NADPH oxidase increased the production of free reactive oxygen radicals can up-regulate vascular endothelial growth factor (VEGF) in retinal cells via nuclear transcription factors (eg. NF-kappaB) potentially promoting retinal neovascularisation and increasing permeability to proteins across the retinal barrier. , 1999). , 2005). 4. Oxidative stress and diabetic retinopathy Diabetic retinopathy pathogenesis is multifactorial, and the precise mechanisms are unclear. , 1998; Koya & King 1998).
Diabetic Retinopathy by M. Ola