By Ingrid S. Gribbestad MD, Kjell I. Gjesdal MD, Gunnar Nilsen MD, Steinar Lundgren MD (auth.), Alan Jackson MBChB (Hons), PhD, FRCP FRCR, David L. Buckley PhD, Geoffrey J. M. Parker PhD (eds.)
Dynamic contrast-enhanced MRI is now confirmed because the method of selection for the overview of tumor microcirculation in vivo. this is often aiding scientific practitioners within the administration of sufferers with stable tumors and is discovering prominence within the evaluate of tumor remedies, together with anti-angiogenics, chemotherapy, and radiotherapy. during this publication, unique at either medical practitioners and uncomplicated scientists, the rules of the tools, their functional implementation, and their software to precise tumor kinds are mentioned by means of the major experts within the box at the present time. The ebook will function a useful single-volume reference overlaying the entire most up-to-date advancements in contrast-enhanced oncological MRI.
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Extra resources for Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Oncology
Manganese is the most successful, and most often clinically used, non-lanthanide based MRI contrast agent, most commonly seen as a chelate of dipyridoxyl diphosphate (Mn-DPDP), a derivative of vitamin B6. Mn-DPDP is also known as Mangafodipir trisodium and is marketed as Teslascan by Nycomed-Amersham. In oncology Mn contrast reagents have been successfully used in the analysis of pancreatic lesions (Diehl et al. 1999; Sahani et al. 2002). In addition, Mn-DPDP has been hailed as a liver-speciﬁc contrast agent as it is sequestered there by Kupffer cells.
Such microvascular parameters have been used to assess, for example, cancer (Griebel et al. 1997; Reddick et al. 1999) and cerebrovascular disease (Edelman et al. 1990; Tsuchida et al. 1997), amongst other pathologies. There are two approaches used in DCE-MRI, based on whether the acquired signal is T1-weighted or T2* (or T2)-weighted (the choice of method is often dictated by the vascular parameters that are being investigated). The primary differences between the two approaches are: (1) The T1-weighted methods (sometimes called “pseudo-steady-state”) typically take longer to Contrast Agents for Magnetic Resonance Imaging acquire the data (5–7 min or more are usually needed to model the data sufﬁciently accurately to give meaningful results, while T2* methods typically take less than 1–2 min, focusing on “ﬁrst-pass” kinetics).
J Magn Reson Imaging 10(3):223–232 Tsao J, Boesiger P, Pruessmann KP (2003) k-t BLAST and k-t SENSE: dynamic MRI with high frame rate exploiting spatiotemporal correlations. Magn Reson Med 50(5):1031– 1042 van Vaals JJ, Brummer ME, Dixon WT, Tuithof HH, Engels H, Nelson RC, Gerety BM, Chezmar JL, den Boer JA (1993) “Keyhole” method for accelerating imaging of contrast agent uptake. J Magn Reson Imaging 3:671–675 Verstraete KL, De Deene Y, Roels H, Dierick A, Uyttendaele D, Kunnen M (1994) Benign and malignant musculoskeletal I.
Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Oncology by Ingrid S. Gribbestad MD, Kjell I. Gjesdal MD, Gunnar Nilsen MD, Steinar Lundgren MD (auth.), Alan Jackson MBChB (Hons), PhD, FRCP FRCR, David L. Buckley PhD, Geoffrey J. M. Parker PhD (eds.)