By Edna M. Mora, Selanere L. Mangala (auth.), Jack A. Roth (eds.)
Cancer gene remedy is a singular treatment that goals the underlying genetic defects within the melanoma telephone. growth during this box has been speedy and gene remedy gives you to additional expand customized melanoma remedy. during this quantity top specialists have contributed their event in constructing gene cures for various cancers. Translational gene remedy ways are emphasised. Chapters comprise discussions of particular gene supply applied sciences in addition to their program to numerous cancers with large discussions of ongoing medical trials. this knowledge might be beneficial to scholars, fellows, scientific investigators, and skilled scientists with an curiosity during this speedily constructing area.
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Additional resources for Gene-Based Therapies for Cancer
The E1A products bind to and inactivate critical cellular proteins, such as the RB family of pocket proteins (Jiang et al. 2006). Inactivation of these proteins propels the cell into unscheduled DNA synthesis, which creates a favorable environment for adenoviral replication. However, forced entry into S phase may trigger p53-mediated apoptosis during the early stage of viral infection, aborting the process of replication. To prevent the p53-induced apoptotic response, adenovirus encodes other early proteins, such as E1B-55K, E4orf6 and E1B-19K, to bind and inactivate p53 and Bax, resulting in a prolonged cell life that ensures the propagation of virions (Jiang et al.
Alexander DJ, Allan WH. Newcastle disease virus pathotypes. Avian Pathol 1974;3(4):269–78. Wheelock EF, Dingle JH. Observations on the repeated administration of viruses to a patient with acute leukemia. A preliminary report. N Engl J Med 1964;271:645–51. Schirrmacher V, Haas C, Bonifer R, Ahlert T, Gerhards R, Ertel C. Human tumor cell modification by virus infection: an efficient and safe way to produce cancer vaccine with pleiotropic immune stimulatory properties when using Newcastle disease virus.
During the last decade, tremendous efforts have been made to address these issues. Since brain tumors are localized diseases that are suitable for gene-based therapies (Table 2), stereotactic intratumoral injection and injection into tumor cavity wall postresection are desirable delivery modes. Due to the infiltrative nature of gliomas, complete remission of the tumor largely depends on the efficient delivery of the therapeutics to the cancerous cells infiltrated into normal brain tissue. Clinical experience with replication-deficient viral vectors revealed minimal delivery 28 Table 2 Specific conditions of malignant gliomas H.
Gene-Based Therapies for Cancer by Edna M. Mora, Selanere L. Mangala (auth.), Jack A. Roth (eds.)