Histological Typing of Lung and Pleural Tumours by W. D. Travis, T. V. Colby, B. Corrin, Y. Shimosato, E. PDF

By W. D. Travis, T. V. Colby, B. Corrin, Y. Shimosato, E. Brambilla (auth.)

ISBN-10: 3540652191

ISBN-13: 9783540652199

ISBN-10: 3642600492

ISBN-13: 9783642600494

The hot WHO category of Lung and Pleural Tumours updates the former thought from 1981 and accommodates many new strategies that experience built due to the fact that point. a couple of newly defined lesions are incorporated in addition to present innovations in papillomas, adenomas, neuroendocrine tumours, adenocarcinomas, mesothelial tumours, and carcinomas with pleomorphic, sarcomatoid and sarcomatous positive factors. the result's a complete type with special definitions and explantory notes illustrated via a hundred and fifty prime quality colour photomicrographs that would advertise uniformity in recording and reporting information nationally and the world over. The WHO panel consisted of 24 individuals from 14 international locations giving a huge foreign enter into this paintings.

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Extra resources for Histological Typing of Lung and Pleural Tumours

Example text

In open biopsy specimens it is evident that small cell carcinomas have a high mitotic rate that averages 60-70 per 2 mm 2 (ten high- 'World Health Organization (1981) Histological typing of lung tumors, 2nd edn. WHO. Geneva 34 Definitions and Explantory Notes power fields), ranging up to over 200 per 2 mm 2 (ten high-power fields) (Table 3, p. 8). The degree of mitotic activity is usually also appreciated on a well-preserved open biopsy specimen, but it may be more difficult to see mitoses in small, crushed bronchoscopic biopsies.

Due to the rarity of these cases little is known concerning the percentage of patients who will develop carcinoid tumours, or how long it takes for the tumours to develop. The obstructive airway disease can be severe and require lung transplantation. Substances produced by the neuroendocrine cells may promote the airway fibrosis. 1 Squamous cell carcinoma (Figs. 19-25) 31 A malignant epithelial tumour showing keratinization and/or intercellular bridges. Keratinization may take the form of squamous pearls or individual cells with markedly eosinophilic dense cytoplasm.

Combined small cell and adenocarcinoma. Epithelial Tumours 33 In the 1981 classification three subtypes of small cell carcinoma were proposed: (1) oat cell carcinoma, (2) small cell carcinoma, intermediate cell type, and (3) combined oat cell carcinoma!. Problems that were subsequently recognized included difficulties in reproducibility and lack of demonstrable clinical significance. In 1988, the International Association for the Study of Lung Cancer (IASLC) pathology panel proposed the following three sUbtypes: (1) small cell carcinoma, (2) mixed small cell/large cell carcinoma, and (3) combined small cell carcinoma.

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Histological Typing of Lung and Pleural Tumours by W. D. Travis, T. V. Colby, B. Corrin, Y. Shimosato, E. Brambilla (auth.)


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