Download e-book for kindle: Hormones, Genes, and Cancer by Brian E. Henderson, Bruce Ponder, Ronald K. Ross

By Brian E. Henderson, Bruce Ponder, Ronald K. Ross

ISBN-10: 0195135768

ISBN-13: 9780195135763

Hormonal carcinogenesis is a vital and debatable sector of present study. as well as accelerating current cancers, can hormones play the function of fundamental cancer causing agents? How do genetic components effect hormone-related melanoma chance? Hormones, Genes, and melanoma addresses those questions. over the last few many years, melanoma examine has curious about exterior environmental causes(e.g., tobacco smoke, viruses, asbestos). With the appearance of recent genetic sequencing thoughts, we're simply now commencing to know how the body's inner environment(i.e., the hormones and development elements that ascertain basic improvement) affects melanoma etiology and prevention. From molecular insights to medical analyses, this quantity offers state of the art info at the complicated interactions among hormones and genes and melanoma. The epidemiology and molecular endocrinology of prostate, breast, uterine, ovarian and testicular melanoma are targeted during this well timed treatise.

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Extra resources for Hormones, Genes, and Cancer

Example text

Other epidemiological studies addressing the hypothesis that the ratio of 2-hydroxylation to 16␣-hydroxylation of estrone is important in breast cancer development have not been supportive. Adlercreutz and coworkers151 determined the urinary estrogen profile, consisting of 13 estrogens, by GC-MS twice in 1 year in 10 premenopausal Finnish women with breast cancer and two control groups, one consuming an omnivorous diet (n ϭ 12) and the other a lactovegetarian diet (n ϭ 11). They found that the ratio of 2-hydroxyestrone to 16␣-hydroxyestrone was highest in the breast cancer group and lowest in the vegetarians.

The reaction involving each of the androgens to the corresponding estrogens is known as aromatization since it involves conversion of the A ring of the androgens to an aromatic ring. 62 Briefly, the following steps are involved, beginning with androstenedione as precursor. First, the methyl group at carbon 19 becomes hydroxylated, giving rise to 19-hydroxyandrostenedione. This is followed by a second hydroxylation step at the same carbon, yielding 19,19-dihydroxyandrostenedione, which may reversibly dehydrate to form 19-ketoandrostenedione.

The present section will discuss the 5␣-reductases and 3␣-HSDs. Little is known about the 5␤-reductases. 5␣-Reductases Molecular cloning studies have revealed the existence of two genes that encode isoenzymes of 5␣-reductases. The isoenzymes are designated types 1 and 2 and have distinct biochemical properties and tissue distributions. They are encoded by the SRD5A1 and SRD5A2 genes, respectively. The type 1 isoenzyme is found primarily in the liver and skin. It is optimally active at an alkaline pH.

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Hormones, Genes, and Cancer by Brian E. Henderson, Bruce Ponder, Ronald K. Ross


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