By Dick Smithells (auth.), Harold Kalter (eds.)
From a evaluate of an previous quantity: 'Both the experimental and the human elements of teratology are awarded during this finished textual content by way of a stellar crew of the world over famous scientists and clinicians....A beneficial source for these interested by experimental teratology and chance evaluate and people requiring basic information regarding the reasons of delivery defects. The remedy of those matters is refined, succinct, and logical.'-American Scientist
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Extra resources for Issues and Reviews in Teratology: Volume 7
1992). Also after CBZ, such features have been described. , a sample of 72 women were analyzed. They had been identified because they had, during pregnancy, expressed a concern about the potential teratogenicity of CBZ. The authors described minor facial defects and finger nail hypoplasia very much resembling those described after maternal use of other anticonvulsants. From this study, it is not possible to say whether dysmorpholic features occur at a different rate after CBZ than after the other commonly used anticonvulsants because comparisons were made with infants of healthy mothers as pointed out by Keller (1989), Scialli and Lione (1989), and Bortnichak et ai.
Murasaki et al. (1988) described the malformation frequency among 115 infants exposed to CBZ in monotherapy: the malformation rate was 14% in this group against 11% for all infants of epileptic mothers studied. A combination of CBZ and valproic acid was associated with the highest recorded malformation risk. Battino et al. (1992b) described malformations in 26 among 315 newborn whose mothers were epileptics (8%). Among them, 61 had been exposed to CBZ in monotherapy - 6 (10%) had malformations.
Med. Genet. 29:716-723. W. B. 1959 Congenital heart block. Arch. Dis. Childh. 34:223-227. W. and Sheppard, S. 1978 Teratogenicity testing in humans: A method demonstrating safety of Bendectin. Teratology 17:31-36. , Sheppard, S. J. 1976 Vitamin deficiencies and neural tube defects. Arch. Dis. Childh. 51:944-950. P. W. 1980 Possible prevention of neural-tube defects by periconceptional vitamin supplementation. Lancet 1:339-340. P. W. 1981 Apparent prevention of neural-tube defects by periconceptional vitamin supplementation.
Issues and Reviews in Teratology: Volume 7 by Dick Smithells (auth.), Harold Kalter (eds.)