Download PDF by Gil Alterovitz, Marco Ramoni: Knowledge-Based Bioinformatics: From analysis to

By Gil Alterovitz, Marco Ramoni

ISBN-10: 0470748311

ISBN-13: 9780470748312

There's an expanding want through the biomedical sciences for a better realizing of knowledge-based platforms and their software to genomic and proteomic study. This ebook discusses knowledge-based and statistical ways, besides purposes in bioinformatics and platforms biology. The textual content emphasizes the combination of other equipment for analysing and studying biomedical facts. This, in flip, can result in leap forward biomolecular discoveries, with functions in customized medicine.Key Features:Explores the basics and purposes of knowledge-based and statistical techniques in bioinformatics and platforms biology.Helps readers to interpret genomic, proteomic, and metabolomic info in figuring out complicated organic molecules and their interactions.Provides worthwhile information on facing huge datasets in wisdom bases, a standard factor in bioinformatics.Written by way of major foreign specialists during this field.Students, researchers, and execs with a heritage in biomedical sciences, arithmetic, records, or machine technological know-how will make the most of this ebook. it is going to even be priceless for readers world wide who are looking to grasp the appliance of bioinformatics to real-world occasions and comprehend organic difficulties that encourage algorithms.

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Additional info for Knowledge-Based Bioinformatics: From analysis to interpretation

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6 15 Capturing novel knowledge Not everything can be considered common knowledge; there are large collections of local-domain knowledge consisting of works and models (published and prepublished) created by individual research groups. This is usually knowledge that has not been completely vetted or validated yet (hypotheses and beliefs), but nonetheless can be accessed by others who wish to refute or corroborate the proposed hypotheses as part of the scientific method. This knowledge is connected to and relies on the fundamentals of biology, which are themselves common knowledge (since they form the basis of scientific common ground).

KDD was intended to take advantage of both wherever possible. , patient outcomes are affected by their genotypes) begin to demonstrate the true symbolic nature of information. That is, data is about tying together relations and attributes, whether it is arranged as tables of values or sets of assertions. The question arises, how can we use this to more efficiently find patterns in data? The key here is understanding that relational data can be generalized as data graphs: collections of nodes connected by edges, analogous to how formal relational knowledge structures are to function (see above).

Another way to understand this, is that if Amy knows X about something, and Bob knows only Y, and X and Y are both required to solve a research problem (possibly unknown to Amy and Bob), then Amy and Bob need to combine their respective sets as common knowledge to solve a given problem. In the real world this manifests itself as experts (or expert systems) who are called upon when there is a gap in knowledge, such as when an oncologist calls on a bioinformatician to help analyze biomarker results.

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Knowledge-Based Bioinformatics: From analysis to interpretation by Gil Alterovitz, Marco Ramoni

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