Barbara Driscoll's Lung Cancer: Diagnostic and Therapeutic Methods and Reviews PDF

By Barbara Driscoll

Prime health care professional scientists and famous researchers describe step by step options for lung melanoma analysis according to the molecular research of medical samples. those specialists evaluate at the moment approved remedies and description a number of novel treatments, together with these in response to gene remedy, immunotherapy, and chemoprevention, and exhibit how those newly superior concepts can provide a greater appreciation of the diagnosis linked to the actual mutation exposed through the approach. those tools use various molecular recommendations, together with the manipulation of gene expression and the alteration of immune prestige, to wrestle lung melanoma.

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4% of the tumors could be correctly diagnosed. The best three triplets were VEGF/FGF/P170, VEGF/P170/TS, and VEGF P170/MT (see Fig. 5, right). 47% of the tumors diagnosed correctly. Table 2 presents the six best pairs and triplets. 3. 31 Se, Sensitivity; Sp, Specificity; CD, Correctly diagnosed. uncertain. Therefore, a number of test systems to detect tumor resistance against cytostatic agents have been developed over the past several years. The following approaches to predictive testing are being investigated: measuring the cellular damage in a monolayer or organ culture, measuring the inhibition of radioactive precursor incorporation, measuring clonogenic cell survival and human tumor xenografts.

Sci. USA 88, 10591–10595. 8. , and Mattern, J. (1979). Pretherapeutic detection of tumour resistance and the results of tumor chemotherapy. Eur. J. Cancer 15, 938–993. 9. Group for sensitivity testing of tumors (KSST) (1981) In vitro short-term test to determine the resistance of human tumors to chemotherapy. Cancer 48, 2127–2135. 10. Volm, M. and Rittgen, W. (2000) Cellular predictive factors for the drug response of lung cancer. Anticancer Res. 20, 3449–3458. CH03,39-52,14pgs 51 07/22/02, 10:45 AM p53 in Lung Cancer 53 4 Clinical Implications of p53 Mutations in Lung Cancer Barbara G.

J. Med. 323, 561–565. 16. , Mate, J. , et al. (1993) Prognostic impact of mutated K-ras gene in surgically resected non-small cell lung cancer patients. Oncogene 8, 2407–2412. 17. , Steinberg, S. , Oie, H. , Mulshine, J. , et al. (1991) ras gene mutations in non-small cell lung cancers are associated with shortened survival irrespective of treatment intent. Cancer Res. 51, 4999–5002. 18. Graziano, S. , Gamble, G. , Newman, N. , Abbott, L. , et al. (1999) Prognostic significance of K-ras codon 12 mutations in patients with resected stage I and II non-small-cell lung cancer.

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Lung Cancer: Diagnostic and Therapeutic Methods and Reviews by Barbara Driscoll


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