Read e-book online Molecular Oncology and Clinical Applications PDF

By R. Dulbecco (auth.), Prof. Dr. A. Cittadini, Prof. Dr. R. Baserga, Prof. Dr. H. M. Pinedo, Prof. Dr. T. Galeotti, Dr. D. Corda (eds.)

ISBN-10: 3034856636

ISBN-13: 9783034856638

ISBN-10: 3034856652

ISBN-13: 9783034856652

The uncomplicated wisdom of telephone biology and molecular genetics in oncology is more and more attracting the curiosity of scientific oncologists and is as regards to achieving a useful software on the bedside. at the moment, it kind of feels transparent that the answer of the melanoma challenge lies in the comprehension of the intimate mechanisms resulting in cellphone transformation and tumor development as weIl as of the cancer-host courting. based on this purpose each fulfillment during this context may enormously increase either prognosis and treatment of neoplastic ailments. This={)ook represents the court cases of the foreign convention o~ melanoma: organic Mechanisms and scientific purposes, held in Rome on November 16-18, 1992. The assembly used to be geared up via the Centro di Ricerche Oncologiche "Giovanni XXIII" of the Catholic collage of Rome and the Consorzio Mario Negri Sud of S. M. Imbaro in collaboration with different colleagues from the schools of Napoli and Bologna. As organizers and pmticipants to the convention we expect the assembly used to be successful, as was once proven through the nice curiosity raised in medical and educational circles. The ebook collects contributions from major scientists in all oncological m·eas starting from molecular biology to immunology, prognosis and remedy. The papers are equipped into 4 sections: I - Molecular elements of mobilephone transformation and progress; II - Membrane receptors and sign transduction; III - versions for brand spanking new therapeutical thoughts; IV - medical functions, following the method that chm·acterized the whole assembly: from molecule to bedside.

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1990) cDNA cloning and characterization of ret activated in a human papillary thyroid carcinoma cellline. Biochem. Biophys. Res. Commun. 162(2): 402-408. , Nakamura, N. and Akyama, M. (1992) Unique association of p53 mutations with undifferentiated buta not with differentiated carcinomas of the thyroid gland. Cancer Res. 52: 1369-1371. Koda, T. (1988) Ret gene from a human stornach cancer. Hokkaido J. Med. Sei. 63: 913-924. , and Vecchio, G. (1992) Characterization of an inversion on the long arm of chromosome 10 juxtaposing ret and DI0S170 and creating the oncogenic sequence RET/PTC.

This interpretation receives a good deal of circumstantial support through the study of human populations. Specific types of tumors can aggregate in families and sometimes occur with the formal transmission characteristics of Mendelian autosomal dominant predisposition (Mulvihill, 1977). It is reasonably easy to construct models for this when the tumors occur singly and are of homogeneous types (Knudson, 1971), but less so when seemingly unrelated tumor types appear to be the phenotypic manifestation of the trait.

1992, Pietrzkowski et al. ; and 6) viral DNA oncogenes, like the SV40 large T antigen, and protooneogenes like e-myb, decrease the growth factors requirements of cells in culture by increasing the expression of IGF-l and IGF-l mRNA. These, and other, experiments lead to the conc1usion that the activation of the IGF-l receptor is required for the growth of manY types of cells, but, more important, that the IGF-l reeeptor is, so to speak, the last growth factor receptor, downstream from all the other growth factors receptors, such as those for PDGF, EGF, interleukin-2, colony-stimulating faetors, etc.

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Molecular Oncology and Clinical Applications by R. Dulbecco (auth.), Prof. Dr. A. Cittadini, Prof. Dr. R. Baserga, Prof. Dr. H. M. Pinedo, Prof. Dr. T. Galeotti, Dr. D. Corda (eds.)


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