By Richard A. Scanlan and Steven R. Tannenbaum (Eds.)
content material: Activation of nitrosamines to organic alkylating brokers / C.J. Michejda, M.B. Kroeger-Koepke, S.R. Koepke, and D.H. Sieh --
Chemical and biochemical differences of [beta]-oxidized nitrosamines / Richard N. Loeppky, Jerry R. Outram, Witold Tomasik, and Wayne McKinley --
Mechanisms of alkylation of DNA by way of N-nitrosodialkylamines / Michael C. Archer and Kwang-Hang Leung --
The metabolism of cyclic nitrosamines / Stephen S. Hecht, G. David McCoy, Chi-Hong B. Chen, and Dietrich Hoffmann --
results of constitution at the carcinogenic habit of nitrosamines / John S. Wishnok --
Structure-activity relationships between N-nitroso compounds / William Lijinsky --
Chemistry of a few N-nitrosamides / Clive N. Berry, Brian C. Challis, Andrew D. Gribble, and Susan P. Jones --
gasoline part reactions of N, N-dimethylhydrazine with ozone and NOx in simulated atmospheres : facile formation of N-nitrosodimethylamine / William P.L. Carter, Ernesto C. Tuazon, Arthur M. Winer, and J.N. Pitts, Jr. --
attainable mechanisms of nitrosamine formation in insecticides / Larry okay. Keefer --
Formation and inhibition of N-nitrosodiethanolamine in an anionic oil-water emulsion / B.L. Kabacoff, R.J. Lechnir, S.F. Vielhuber, and M.L. Douglass --
The function of micro organism in nitrosamine formation / D. Ralt and S.R. Tannenbaum --
Formation of N-nitroso compounds in meals / J. Ian grey --
N-nitrosomorpholine synthesis in rodents uncovered to nitrogen dioxide and morpholine / Sidney S. Mirvish, Phillip Issenberg, and James P. Sams --
blockading nitrosation reactions in vivo / William J. Mergens and Harold L. Newmark --
prevalence of N-nitrosamines within the office : a few contemporary advancements / D.H. positive and D.P. Rounbehler --
aid of human publicity to environmental N-nitroso compounds / R. Preussmann, B. Spiegelhalder, and G. Eisenbrand --
N-nitrosamines in beer / Mario M. Mangino, Richard A. Scanlan, and Terence J. O'Brien --
Formation, incidence, and carcinogenicity of N-nitrosamines in tobacco items / Dietrich Hoffmann, John D. Adams, Klaus D. Brunnemann, and Stephen S. Hecht --
N-nitrosamine formation in soil from the herbicide glyphosate and its uptake via crops / Shahamat U. Khan --
response of meat components with nitrite / R.G. Cassens, ok. Izumi, M. Lee, M.L. Greaser, and J. Lozano --
N-nitroso compounds : vitamin and melanoma tendencies : an method of the prevention of gastric melanoma / John H. Weisburger --
The microecology of gastric melanoma / Pelayo Correa and Steven R. Tannenbaum --
Analytical equipment for nitrosamines / Phillip Issenberg --
Pesticide-derived nitrosamines : prevalence and environmental destiny / James E. Oliver --
aid of nitrosamine impurities in pesticide formulations / G.W. Probst --
coverage and regulatory points of N-nitroso contaminants in pesticide items / Gunter Zweig and Willa Garner.
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Extra info for N-Nitroso Compounds
To understand the reasons f o r t h i s , more work i s necessary on target organ metabolism of NPYR and on the formation and p e r s i s t e n c e of s p e c i f i c DNA adducts. ch004 Ν'-Nitrosonornicotine (NNN) NNN i s f o r m a l l y a d e r i v a t i v e o f NPYR, but the p y r i d i n e r i n g has a marked e f f e c t on i t s metabolism and c a r c i n o g e n i c i t y . NNN induces lung adenomas i n mice, esophageal and nasal c a v i t y tumors i n r a t s , and t r a c h e a l and nasal c a v i t y tumors i n S y r i a n golden hamsters (29, 30, 31).
As expected (10,11), both propanol isomers were formed, the t o t a l y i e l d i n this case being almost quantitative. Formation of both 2-propanol and 1-propanol following meta bolism of NDPA by rat l i v e r fractions in vitro with water as the nucleophile, indicates that the propyl cation i s indeed formed as shown i n Figure 1. IJext, four male Sprague-Dawley rats were administered NDPA[2,3- H] by intraperitoneal injection (12). After 12 hours, the animals were s a c r i f i c e d , and RNA and DNA were isolated from the combined l i v e r s by standard procedures.
C. Carcinogenesis, ( i n press). RECEIVED August 10, 1981. ch003 Alkylation 4 The Metabolism of Cyclic Nitrosamines S T E P H E N S. H E C H T , G . D A V I D M c C O Y , C H I - H O N G B . ch004 Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla, NY 10595 Investigations of the in vitro and in vivo metabo lism of the cyclic nitrosamines N-nitrosopyrrolidine, N'-nitrosonornicotine, N-nitrosopiperidine, N-nitrosohexamethyleneimine, N-nitrosomorpholine, and related compounds are reviewed.
N-Nitroso Compounds by Richard A. Scanlan and Steven R. Tannenbaum (Eds.)