By Ma. Del Camen Mejia Vazquez, Samuel Navarro
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Extra info for New Approaches in the Treatment of Cancer (Cancer Etiology, Diagnosis and Treatments)
Epigenetic Therapy The epigenetic changes are alterations in the genes‘ expression that are not accompanied by modifications in the sequence of DNA. This implies that these alterations can be transferred from cell to cell, but can be reverted through inducing the correct expression of a gene or protein. The silencing of genes or proteins is a key factor for the cellular operation. The two most understood epigenetic mechanisms today are the DNA methylation and the histones acetylating; in the first, the methylation works like a protector of genetic silencing and with the second, modifications in the chromatin structure are induced [24,25].
43-69 ISBN 978-1-61728-304-8 © 2010 Nova Science Publishers, Inc. Chapter III MOLECULAR-GUIDED THERAPY OF NEUROBLASTOMA Eva Villamón1, Marta Piqueras1, Elena Grau2, Adela Cañete2, Victoria Castel2 and Rosa Noguera1,,# 1 2 University of Valencia, Spain Hospital La Fe, Valencia, Spain ABSTRACT Combination therapy has improved outcome for some malignancies such as neuroblastoma (NB), the most common pediatric solid tumor. Despite this advance, progression-free survival for children with advanced disease is 45% at best, even with double autologous stem cell transplantation.
Angiosarcoma of the eyelid and periorbital region. Experience in Leiden with iridium192 brachytherapy and low-dose doxorubicin chemotherapy. Orbit, 2008 27, 5-12.  Mejia, C; Ruiz-Azuara, L. Casiopeinas IIgly and IIIia induce apoptosis in medulloblastoma cells. Pathology and Oncology Research, 2008 14, 467-472. 30 J. Christian Moreno-Vargas, Perla Reyes-Fernandez, Melissa P. Monroy-Romo P et al.  Viswanathan, AN; Erickson, BA. Three-Dimensional Imaging in Gynecologic Brachytherapy: A Survey of the American Brachytherapy Society.
New Approaches in the Treatment of Cancer (Cancer Etiology, Diagnosis and Treatments) by Ma. Del Camen Mejia Vazquez, Samuel Navarro